-
Multiplexed programmable RNA-guided
endonuclease (Symbiotic©) designed to
inactivate any target genes including
antibiotic resistance genes.Delivered into the bacterial cell
by Transmids© or commensal
bacterial conjugationExpressed within the bacterial
genome to produce guide
RNAs and the endonucleaseGuide RNA linked to
endonuclease provide
target specificitySymbiotic© seeks, finds
and inactivates antibiotic
resistance genes and
restores antibiotic sensitivity -
Multiplexed programmable RNA-guided
endonuclease (Symbiotic©) designed to
inactivate any target genes including
antibiotic resistance genes.Delivered into the bacterial cell
by Transmids© or commensal
bacterial conjugationExpressed within the bacterial
genome to produce guide
RNAs and the endonucleaseGuide RNA linked to
endonuclease provide
target specificitySymbiotic© seeks, finds
and inactivates antibiotic
resistance genes and
restores antibiotic sensitivity