-
Multiplexed programmable RNA-guided
endonuclease (Symbiotic©), when provided
in a commensal, probiotic bacterium will
be transferred by conjugation into patients’
bacteria where they will inactivate
targeted genes.Plasmids encoding Symbiotics© will
replicate in target bacterial cells and be
passed on after cell division into offspring
cells. They can also continue to spread by
conjugation to other bacteria.Symbiotics© will inactivate any resistance
genes attempting entry by conjugation
thereby protecting the patient from the
spread of antibiotic resistance genes in
their microbiome. -
Multiplexed programmable RNA-guided
endonuclease (Symbiotic©), when provided
in a commensal, probiotic bacterium will
be transferred by conjugation into patients’
bacteria where they will inactivate
targeted genes.Plasmids encoding Symbiotics© will
replicate in target bacterial cells and be
passed on after cell division into offspring
cells. They can also continue to spread by
conjugation to other bacteria.Symbiotics© will inactivate any resistance
genes attempting entry by conjugation
thereby protecting the patient from the
spread of antibiotic resistance genes in
their microbiome.